Chloroma

Ans. is ‘a’ i.e., AML

Clinical features ofAML

o The clinical findings in AML are similar to those in ALL i.e., suppression of normal hematopoiesis in the marrow that results in ‑

(i)AnemiaFatigue, Pallor

(ii)Neutropenia   —->  Infection, Fever

(iii)Thrombocytopenia —› Spontaneous mucosal and cutaneous bleeding. This the most striking clinical feature.

Others

o Cells with multiple Auer rods are called “Faggot cells” are seen in M₁ type of AML.

o Tumor cells in acute promyelocytic leukemia (M₃) release procoagulant and fibrinolytic factors that cause disseminated intravascular coagulation (DIC).

o Monocytic differentiation type (M₄ and M₃) may present with infiltration of skin (leukemia cutis) and gingival hypertrophy.

o Chloromas (granulocytic sarcomas or myeloblastomas) are localize masses composed of myeloblasts in the absence of marrow or peripheral blood involvement.

o Lymphodenopathy, Hepatosplenomegaly, CNS involvement and testicular involvement are less common than AML.

Ans. is ‘c’ i.e., Haemopoetic cell