Classification Of Anti-Microbials

CLASSIFICATION OF ANTIMICROBIALS

Q. 1 All drug inhibit bacterial cell wall synthesis EXCEPT
 A Spectinomycin    
 B Vancomycin
 C Aztreonam
 D Cephalexin
 
Q. 1 All drug inhibit bacterial cell wall synthesis EXCEPT
 A Spectinomycin    
 B Vancomycin
 C Aztreonam
 D Cephalexin
 
Ans. A

Explanation:

Spectinomycin is an aminocyclitol antibiotic that inhibits bacterial protein synthesis. The other drugs all inhibit bacterial cell wall synthesis. Vancomycin and bacitracin inhibit early steps in the biosynthesis of the peptidoglycan component of the cell wall, whereas 3– lactams such as aztreonam (a monobactam), penicillins, cephalosporins, and carbapenems inhibit the cross-linking (transpeptidation) of the cell wall peptidoglycan polymers.


Q. 2 All of the following are true regarding cephalosporins, except:
 A Bacteriocidal agents
 B Active against only gram negative
 C Resistant to beta lactamases by Bird generation cephalosporins
 D None of the above
Q. 2 All of the following are true regarding cephalosporins, except:
 A Bacteriocidal agents
 B Active against only gram negative
 C Resistant to beta lactamases by Bird generation cephalosporins
 D None of the above
Ans. B

Explanation:

Bacteriocidal agents


Q. 3

Cell wall synthesis is inhibited by all of the following, EXCEPT:

 A

Amoxycillin

 B

Penicillin G

 C

Tetracycline

 D

Cefotetan

Q. 3

Cell wall synthesis is inhibited by all of the following, EXCEPT:

 A

Amoxycillin

 B

Penicillin G

 C

Tetracycline

 D

Cefotetan

Ans. C

Explanation:

Tetracyclines act by inhibiting the protein synthesis and they do not inhibit the cell wall synthesis. 

 
Antibiotics that act by inhibiting cell wall synthesis are Penicillins Cephalosporins, Cycloserine, Vancomycin and Bacitracin.
 
Ref: KDT, 6th Edition, Page 668; Essentials of Medical Pharmacology By K D Tripathi, 6th Edition, Page 738; An Evaluation of Current Cholera Treatment By Bhattacharya SK, National Institute of Cholera and Enteric Diseases (2003). 4 (2): 141

Quiz In Between


Q. 4

Antipseudomonal action is a characteristic of which of the following  antimicrobials?

 A

Cefopodoxime

 B

Cefoperazone

 C

Cefotetan

 D

Ceforanide

Q. 4

Antipseudomonal action is a characteristic of which of the following  antimicrobials?

 A

Cefopodoxime

 B

Cefoperazone

 C

Cefotetan

 D

Ceforanide

Ans. B

Explanation:

Cefoperazone is 3rd generation cephalosporin, which is active against gram positive as well as gram negative bacterias. It is one of the few antibiotics that have anti-pseudomonal action. It exerts its action by inhibiting bacterial cell wall growth. Main adverse effect of this drug is Hypothrombinemia and Disulfiram reaction.

Ref: Sherwood L. Gorbach, John G. Bartlett, Neil R. Blacklo (2004), Chapter 19, “Cephalosporins”, In the book, “Infectious Diesases”, 3rd Edition, Lippincott Publications, USA, Page 196


Q. 5

Drug that inhibits cell wall synthesis is?

 A

Tetracyc I ins

 B

Penicillins

 C

Aminoglycosides

 D

Chloramphenicol

Q. 5

Drug that inhibits cell wall synthesis is?

 A

Tetracyc I ins

 B

Penicillins

 C

Aminoglycosides

 D

Chloramphenicol

Ans. B

Explanation:

Ans. is ‘b’ i.e., Penicillins


Q. 6

Which of the following Antimicrobials has antipseudomonal action –

 A

Cefopodoxime proxetil

 B

Ceforanide

 C

Cefotetan

 D

Cefoperazone

Q. 6

Which of the following Antimicrobials has antipseudomonal action –

 A

Cefopodoxime proxetil

 B

Ceforanide

 C

Cefotetan

 D

Cefoperazone

Ans. D

Explanation:

Ans. is ‘d’ i.e., Cefoperazone

Quiz In Between


Q. 7

Which of the following statements is not true about Tacrolimus –

 A

It is macrolide antibiotic

 B

It is indicated for the prophylaxis of organ transplant rejection

 C

Glucose intolerance is a well recognized side effect

 D

It can be safely administered with any nephrotoxic drug

Q. 7

Which of the following statements is not true about Tacrolimus –

 A

It is macrolide antibiotic

 B

It is indicated for the prophylaxis of organ transplant rejection

 C

Glucose intolerance is a well recognized side effect

 D

It can be safely administered with any nephrotoxic drug

Ans. D

Explanation:

Ans. is ‘d’ i.e., It can be safely administered with any nephrotoxic drug


Q. 8

Fk-506 is a –

 A

It is a macrolide antibiotic

 B

Immunoglobulin antibody

 C

Non depolarising muscle relaxant

 D

Opioid analgesic

Q. 8

Fk-506 is a –

 A

It is a macrolide antibiotic

 B

Immunoglobulin antibody

 C

Non depolarising muscle relaxant

 D

Opioid analgesic

Ans. A

Explanation:

Ans. is ‘a’ i.e., It is a macrolide antibiotic

o Fk-506 is commonly known as Tacrolimus.

o Tacrolimus is a macrolide antibiotic produced by streptomyces tsukubaensis.


Q. 9

Drug which inhibit protein synthesis are all of the following except:   

March 2007

 A

Tetracycline

 B

Chloramphenicol

 C

Erythromycin

 D

None

Q. 9

Drug which inhibit protein synthesis are all of the following except:   

March 2007

 A

Tetracycline

 B

Chloramphenicol

 C

Erythromycin

 D

None

Ans. D

Explanation:

Ans.  d none

Drugs which act by inhibiting protein synthesis:

  • Aminoglycosides (streptomycin, amikacin, tobramycin, neomycin, etc.),
  • Spectinomycin
  • Chloramphenicol
  • Clindamycin
  • Tetracycline (and minocycline, doxycycline, etc.)
  • Erythromycin (and azithromycin)
  • Fusidic acid
  • Linezolid

Penicillin/beta-lactamase antibiotics act by interfering with the synthesis of bacterial cell wall.

Quiz In Between


Q. 10

Bacteriostatic anti TB drug ‑

 A

INH

 B

Rifampicin

 C

Ethambutol

 D

Pyrazinamide

Q. 10

Bacteriostatic anti TB drug ‑

 A

INH

 B

Rifampicin

 C

Ethambutol

 D

Pyrazinamide

Ans. C

Explanation:

Ans. is ‘c’ i.e., Ethambutol

Remember the following facts

  • All cell wall synthesis inhibitors are bactericidal.
  • All antibacterial drugs that act on cell membrane are bactericidal.
  • All first line antitubercular drugs are bactericidal except ethambutol that is bacteriostatic.
  • All protein synthesis inhibitors are bacteriostatic except aminoglycosides & streptogramins which are bactericidal.
  • All drugs affect intermediary metabolism are bacteriostatic.
  • Now, it will be very easy to remember the following table

Q. 11

Following drugs are cell wall synthesis inhibitors except‑

 A

Colistin

 B

Fosfomycin

 C

Bacitracin

 D

Cycloserine

Q. 11

Following drugs are cell wall synthesis inhibitors except‑

 A

Colistin

 B

Fosfomycin

 C

Bacitracin

 D

Cycloserine

Ans. A

Explanation:

Ans. is ‘a’ i.e., Colistin

Quiz In Between



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