Kallman syndrome
Q. 1
A 20 yr old female presents with primary amenorrhea. She has low LH, FSH, estrodial levels. She has anosmia and no secondary sex characteristics on examination. What is the likely diagnosis?
| A |
Kartagener syndrome |
|
| B |
Kallman syndrome |
|
| C |
Alport’s syndrome |
|
| D |
None |
Q. 1
A 20 yr old female presents with primary amenorrhea. She has low LH, FSH, estrodial levels. She has anosmia and no secondary sex characteristics on examination. What is the likely diagnosis?
| A |
Kartagener syndrome |
|
| B |
Kallman syndrome |
|
| C |
Alport’s syndrome |
|
| D |
None |
Ans.
B
Explanation:
Kallmann syndrome
- Kallmann syndrome is caused from defective gonadotropin releasing hormone (GnRH) synthesis.
Clinical features-
- Anaemia & hyposmia due to olfactory bulb agenesis & hypophasia.
- Color blindness, optic atrophy, nerve deafness.
- Cleft palate, cryptoorchidism & mirror movements (neurological defects)
- In males- delayed puberty, micropenis.
- In females- primary amenorrhea, failure of secondary sexual development.
- Low LH & FSH levels & sex steroids.
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