Antiphospholipid antibody syndrome-Management If APLA is diagnosed based on H/O Abortion then aspirin along with low molecular weight heparin has to be given Aspirin: • Aspirin low doses= 50-100mg (80mg) • Started-Urine Pregnancy Test (UPT) +ve • Continued throughout Pregnancy • Stopped 4-6 days before labor Heparin: Started- Only after confirmation of IU pregnancy […]
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Aspirin CHEMISTRY: Aspirin is Acetyl salicylic Acid. PHARMACOKINETICS: Absorption: Well from stomach & upper small intestine Distribution: wide , crosses placental barrier PPL: In 1-2hrs. t1/2: 15 min. Metabolism: Rapid hydrolysis by Esterases in blood & tissues in to Salicylate & Acetic Acid. Salicylate is 80-90-% PPB 20 MOA: Anti-inflammatory: Irreversibly acetylates both isoforms of
Aspirin Q. 1 At usual therapeutic doses (blood levels), expected effects of aspirin include which of the following? A Efficacy greater than acetaminophen as an anti-inflammatory agent B Efficacy less than acetaminophen for relieving simple headache pain C Inhibited growth, or killing, of bacteria that cause fever as a symptom of infection D Inhibition of
