Blood brain barrier BBB Locations: → Formed by TIGHT JUNCTIONS & FOOT PROCESSES OF ASTROCYTES. → ABSENT BBB = CIRCUMVENTRICULAR ORGANS (mnemonic – SOAP) → S= Subfornical organ; O – Organum Vasculosum of Lamina Terminalis; A – Area Postrema; P – Posterior Pituitary BBB Permeability: PERMEABLE Substance: • Glucose (GLUT-1), • Water (Aquaporin-4), • Gases […]
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Blood Brain Barrier BLOOD-BRAIN BARRIER Physiological barrier to movement of substances in & out of brain interstitial tissues. ANATOMICAL BASIS: Depends mainly on special structure in brain capillaries & their endothelial cells. Endothelial cells are joined by ‘Tight-Junction’, reducing capillary permeability. Capillaries are surrounded by glial cell foot process (especially astrocytes). Expands forming complete sheath around capillaries. FUNCTIONS: Maintains environment in
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BLOOD BRAIN BARRIER Q. 1 Blood brain barrier is formed by which of the following cells? A Schwann cells B Oligodendrocytes C Astrocytes D Microglia Q. 1 Blood brain barrier is formed by which of the following cells? A Schwann cells B Oligodendrocytes C Astrocytes D Microglia Ans. C Explanation: Oligodendrocytes and Schwann cells are
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