Tag: Degradation of Purine Nucleotides

Degradation of Purine Nucleotides

Degradation of Purine Nucleotides

Q. 1

Uric acid is formed in humans in

 A

Liver

 B

Kidney

 C

GIT mucosa

 D

Joints

Q. 1

Uric acid is formed in humans in

 A

Liver

 B

Kidney

 C

GIT mucosa

 D

Joints

Ans. B

Explanation:

GIT mucosa

Most of the dietary purines are converted to uric acid in lhe intestinal’mucosal cell only. Intestinal bacterialJlora is intolved in degradation of the rest of dietary purines that remain unabsorbed.


Q. 2

A patient with increased Hypoxanthine and Xanthine in blood with hypouricemia which enzyme is deficient?

 A

HGPRTase

 B

Xanthine oxidase

 C

Adenosine deaminase

 D

APRtase

Q. 2

A patient with increased Hypoxanthine and Xanthine in blood with hypouricemia which enzyme is deficient?

 A

HGPRTase

 B

Xanthine oxidase

 C

Adenosine deaminase

 D

APRtase

Ans. B

Explanation:

  • Hypouricemia- Hypouricemia and increased excretion of hypoxanthine and xanthine are associated with xanthine oxidase deficiency.
  • Lesch-Nyhan Syndrome- The Lesch-Nyhan syndrome, an overproduction hyperuricemia characterized by frequent episodes of uric acid lithiasis and a bizarre syndrome of selfmutilation reflects a defect in hypoxanthine-guanine phosphoribosyltransferase, an enzyme of purine salvage.
  • Adenosine Deaminase Deficiency-  Adenosine deaminase deficiency is associated with an immunodeficiency disease in which both thymus-derived lymphocytes (T cells) and bone marrow-derived lymphocytes (B cells) are sparse and dysfunctional. Patients suffer from severe immunodeficiency.
  • Purine Nucleoside Phosphorylase Deficiency- Purine nucleoside phosphorylase deficiency is associated with a severe deficiency of T cells but apparently normal B cell function

Quiz In Between



Degradation of Purine Nucleotides

Degradation of Purine Nucleotides


CATABOLISM OF PURINE NUCLEOTIDES

  • Human catabolises purine to uric acid.
  • In higher primates, Allantoin by enzyme uricase is the end product.
  • Adenine nucleotides catabolism- liver, heart muscle, Skeletal muscle, GIT mucosa.
  •  Guanine nucleotides catabolism- liver, spleen, kidney, pancreas, GIT mucosa.
  •  First metabolic product of purines is Xanthine.

Exam Important

  1. Human catabolise purines (adenine and guanine) to uric acid.
  2. First metabolic product of purines is xanthine.
  3. In non primate mammals, uric acid is converted to water soluble  allantion by enzyme uricase.
  4. The end product of purine catablism is uric acid, which is excreted.
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