RNA Polymerase (RNAP) RNA Polymerase (RNAP) RNA polymerase (ribonucleic acid polymerase), both abbreviated RNAP or RNApol, official name DNA-directed RNA polymerase, is a member of a family of enzymes that are essential to life. RNAP locally opens the double-stranded DNA (usually about four turns of the double helix) so that one strand of the exposed nucleotides can be used as a template for the synthesis of RNA, […]
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RNA Polymerase (RNAP) Q. 1 RNA polymerase recognizes? A Promoter site B Initiation site C Regulator site D Stop site Q. 1 RNA polymerase recognizes? A Promoter site B Initiation site C Regulator site D Stop site Ans. A Explanation: (40) Promoter site REF: Harper 27`h ed p. 349 RNA polymerase has sigma sub unit
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POST TRANSCRIPTIONAL MODIFICATION OF RNA The primary transcripts of both prokaryotic and eukaryotic tRNA and rRNA are post-transcriptionally modified by cleavage of the original transcripts by ribonucleases. In Prokaryotes mRNA are is not subjected to post-transcriptional processing. In eukaryotes, The collection of all the primary transcripts synthesized in the nucleus by RNA polymerase II is known as heterogeneous nuclear
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POST TRANSCRIPTIONAL MODIFICATION OF RNA Q. 1 Which of the following type of RNA has the splicing activity as a function? A mRNA B snRNA C tRNA D rRNA Q. 1 Which of the following type of RNA has the splicing activity as a function? A mRNA B snRNA C tRNA D rRNA Ans. B
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Disorders of heme biosynthesis Disorders of heme biosynthesis porphyrias are a group of inborn errors (or occasionally acquired) defects of heme biosynthesis. This results in in the accumulation and increased excre-tion of porphyrins or porphyrin precursors. The mutations that cause the porphyrias are heterogenous. Each porphyria results in the accumulation of a unique pattern of intermediates caused
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Disorders of heme biosynthesis Q. 1 A girl on sulphonamides developed abdominal pain and presented to emergency with seizure. What is the probable diagnosis? A Acute intermittent porphyria B Congenital erythropoietic porphyria C Infectious mononucleosis D Kawasaki disease Q. 1 A girl on sulphonamides developed abdominal pain and presented to emergency with seizure. What is
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xenobiotics A xenobiotic is a compound that is foreign to the body may be accidentally ingested or taken as drugs or compounds produced in the body by bacterial metabolism (Greek, xenos = strange). They are metabolized, a process called biotransformation(detoxification). Metabolism of xenobiotics in two phases (phase I and phase II). The cytochrome P450 enzymes are
xenobiotics Q. 1 In metabolism of xenobiotics all of the following reactions occur in phase one except? A Oxidation B Reduction C Conjugation D Hydrolysis Q. 1 In metabolism of xenobiotics all of the following reactions occur in phase one except? A Oxidation B Reduction C Conjugation D Hydrolysis Ans. C Explanation: Conjugation[Ref. K.D.T. 7″/e
RNA editing RNA editing RNA editing is a process through which the nucleotide sequence specified in the genomic template is modified to produce a different nucleotide sequence in the transcript. Even after mRNA has been fully processed, it may undergo additional posttranscriptional modification in which a base in the mRNA is altered. This is known as
RNA editing Q. 1 Apoprotein A is found in : A Chylomicrons B VLDL C HDL D LDL Q. 1 Apoprotein A is found in : A Chylomicrons B VLDL C HDL D LDL Ans. C Explanation: C i.e. HDL Q. 2 Apo B48 and apo 13,00 are expressed as two different apoproteins because of
