FIBRINOLYTIC DRUGS Q. 1 The following statements regarding streptokinase are true, except: A It is a protein produced by streptococci. B Its complex with plasminogen is inhibited by aIpha2-anti plasmin. C It may rarely produce anaphylaxis D It is initially given as a loading dose. Q. 1 The following statements regarding streptokinase are true, except: […]
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FIBRINOLYTIC DRUGS FIBRINOLYTIC DRUGS Also referred as “thrombolytics”. Are drugs activating plasminogen to form plasmin & helping thrombus lysis. MOA: Insoluble fibrin molecules are broken down to soluble fragments by plasmin. Plasmin is generated from plasminogen, by tissue plasminogen activator (tPA). tPA selectively activates fibrin-bound plasminogen in thrombus. Excess plasmin generated is inactivated by circulating
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