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First Pass Metabolism

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First Pass Metabolism INTRODUCTION & MOA: First-pass effect – Phenomenon of drug metabolism whereby drug concentration is greatly reduced before reaching systemic circulation & its concerned target tissue. Mostly occurs with orally administered drug – Due to vulnerability to metabolizing enzymes in intestinal wall & liver. Finally transported via portal vein to liver for metabolization. Hence, referred as “Presystemic […]

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First Pass Metabolism

First pass metabolism Q. 1 A drug administered through which of the following routes undergo high first pass metabolism? A Oral B Sublingual C I.V D I.M Q. 1 A drug administered through which of the following routes undergo high first pass metabolism? A Oral B Sublingual C I.V D I.M Ans. A Explanation: First

First Pass Metabolism

First Pass Metabolism

First Pass Metabolism

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