A 35 years old female presented with painful blisters over oral mucosa and genital areas. She gave the history of similar lesions in the past. A biopsy from the lesion showed a suprabasal split on histopathology. Immunofluorescence microscopy revealed intercellular IgG deposits as shown below. What is the most likely diagnosis?
A. Dermatitis herpetiformis
B. Pemphigus vulgaris
C. Behcet’s disease
D. Allergic dermatitis
Ans: B. Pemphigus vulgaris
(Ref Harrison 19/e p370, 18/e p426-428; Fitzpatrick 7/e p432-441; Rooks 8/e p40.27, 13.19, 10 12-10.28).
Pemphigus vulgaris on immunofluorescence:
- Suprabasal split and intercellular IgG deposits with fish net appearance.