Differential diagnosis of leucocoria
1. Retinoblastoma
2. Congenital Cataract
3. Persistent Hyperplastic primary vitreous [PHPV]
- Most difficult to d/d from Retinoblastoma
FATES OF VITREOUS:
| Before Birth | After Birth |
| • Primary Vitreous | → Disappears (retention → PHPV) |
| • Secondary Vitreous | → Normal |
| • Tertiary Vitreous | → Zonules |
D/D of PHPV from RB:
PHPV:
- Always U/L
- Only seen in small eye (microphthalmos)
4. Coat’s Disease
- Boys
- 1st decade of life (7-8 yrs.)
5. ROP
6. Toxocariasis
7. Endophthalmitis
8. Retinal Detachment
9. Norrie’s disease
10. Coloboma