CHOLESTEROL SYNTHESIS
CHOLESTEROL SYNTHESIS
- Cholesterol is the major sterol in humans.
- Major component in plasma membrane.
Synthesis of Cholesterol
- Major sites- Liver, adrenal cortex, testis, ovaries and intestine.
- Cell organelle- endoplasmic reticulum and cytoplasm
- First material is Acetyl CoA.
- Acetyl- CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)
- Then HMG-CoA is converted to mevalonate by HMG-CoA reductase, (the key regulatory enzyme of cholesterol synthesis)
Exam Important
- Cholesterol is the major sterol in humans.
- Major sites- Liver, adrenal cortex, testis, ovaries and intestine.
- Cell organelle- endoplasmic reticulum and cytoplasm
- First material is Acetyl CoA.
- Acetyl- CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)
- Then HMG-CoA is converted to mevalonate by HMG-CoA reductase, (the key regulatory enzyme of cholesterol synthesis)
Don’t Forget to Solve all the previous Year Question asked on CHOLESTEROL SYNTHESIS
