LITHIUM – PSYCHIATRIC USAGE
LITHIUM – PSYCHIATRIC USAGE
Indications of lithium in psychiatric disorders:
- Used for treatment of acute episodes (both mania & depression).
- Effective treatment for acute mania – Effective serum concentration for acute mania treatment is 1.0-1.5 mEq/ dl.
- Antimanic efficacy of lithium is more than its antidepressive efficacy.
- Prophylaxis in bipolar disorder.
- Maintenance treatment with lithium decreases frequency, severity & duration of manic & depressive episodes in patients with bipolar disorders.
- Serum concentration required for maintenance treatment is 0.6-1.2 mEq/dl.
- In schizoaffective disorders.
- As an adjuvant to antidepressants in major depressive disorder.
Other uses:
- Obsessive-compulsive disorder
- Aggression
- Headache (cluster, migraine)
- Gout
- Epilepsy
- Movement disorders
- Neutropenia
- Ulcerative colitis.
Exam Important
- Lithium is used in effective treatment for acute mania & its effective serum concentration is 1.0-1.5 mEq/ dl.
- Serum lithium concentration required for maintenance treatment is 0.6-1.2 mEq/dl.
- Lithium is also used for headache (cluster, migraine) & neutropenia.
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