Ethylene glycol & Boric acid poisoning
Which of the properties accounts for ethanol’s use in ethylene glycol poisoning?
| A |
Competitive inhibitor of NADPH oxidase |
|
| B |
Competitive inhibitor of alcohol dehydrogenase |
|
| C |
Competitive inhibitor of aldehyde dehydrogenase |
|
| D |
Non-competitive inhibitor of aldehyde dehydrogenase |
Which of the properties accounts for ethanol’s use in ethylene glycol poisoning?
| A |
Competitive inhibitor of NADPH oxidase |
|
| B |
Competitive inhibitor of alcohol dehydrogenase |
|
| C |
Competitive inhibitor of aldehyde dehydrogenase |
|
| D |
Non-competitive inhibitor of aldehyde dehydrogenase |
Ethanol acts by competing with ethylene glycol for alcohol dehydrogenase, the first enzyme in the degradation pathway.
Because ethanol has a much higher affinity for alcohol dehydrogenase, about a 100-times greater affinity, it successfully blocks the breakdown of ethylene glycol into glycoaldehyde, which prevents the further degradation.
Ref: Lehninger Principles of Biochemistry, 4th Edition, Page 336; Updates in Emergency Medicine By John Cahill, 2002, Page 115
Antidote for Ethylene glycol poisoning-
| A |
Methyl violet |
|
| B |
Methyl violet |
|
| C |
Fomepizole |
|
| D |
All |
Antidote for Ethylene glycol poisoning-
| A |
Methyl violet |
|
| B |
Methyl violet |
|
| C |
Fomepizole |
|
| D |
All |
Ans. is ‘c’ i.e., Fomepizole
o I.V. fomepizole or ethanol is given in ethylene glycol poisoning.
o Fomepizole (an alcohol dehydrogenase inhibitor) is the DOC.
Ethanol is used for ethylene glycol poisoning because it is a:
JIPMER 13
| A |
Competitive inhibitor of aldehyde dehydrogenase |
|
| B |
Higher affinity for alcohol dehydrogenase |
|
| C |
Chemically combines and neutralizes ethylene glycol |
|
| D |
A and B |
Ethanol is used for ethylene glycol poisoning because it is a:
JIPMER 13
| A |
Competitive inhibitor of aldehyde dehydrogenase |
|
| B |
Higher affinity for alcohol dehydrogenase |
|
| C |
Chemically combines and neutralizes ethylene glycol |
|
| D |
A and B |
Ans. Higher affinity for alcohol dehydrogenase
Competitive inhibitor of alcohol dehydrogenase [Ref Lehninger Principles of Biochemistry 4th/e p. 336]
Ethylene glycol when ingested affects kidney by forming:
NEET 13
| A |
Formaldehyde |
|
| B |
Oxalates |
|
| C |
Phytates |
|
| D |
Phosphates |
Ethylene glycol when ingested affects kidney by forming:
NEET 13
| A |
Formaldehyde |
|
| B |
Oxalates |
|
| C |
Phytates |
|
| D |
Phosphates |
Ans. Oxalates
