Hemoglobinopathies

HEMOGLOBINOPATHIES HEMOGLOBINOPATHIES It is the family of genetic disorders caused by production of a structurally abnormal hemoglobin molecule, synthesis of insufficient quantities of normal hemoglobin, or, rarely, both. variants leading to hemoglobinopathies may be either alpha chain variants or beta chain variants. Abnormalities in the primary sequence of globin chains lead to hemoglobinopathies,e.g. HbS (qualitative hemoglobinopathy) Abnormalities in the rate […]