Mitochondrial changes in cell injury Mitochondrial changes during cell injury are explained in a pictorial flow chart Reversible cell injury-results in swelling & amorphous deposits in mitochondria Irreversible cell injury-results in swelling with vacuoles & large deposits
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Nuclear changes in cell injury Nuclear changes in cell injury are explained in a flowchart. Reversible cell injury-Results in clumped chromatin in nucleus Irreversible cell injury-Results in karyolysis, karyorrhexis, pyknosis
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Irreversible cell injury Q. 1 Irreversible cell injury is indicated by – A Accumulation of calcium in mitochondria B Myelin figures C ATP depletion D Shifting of ribosomes Q. 1 Irreversible cell injury is indicated by – A Accumulation of calcium in mitochondria B Myelin figures C ATP depletion D Shifting of ribosomes Ans. A
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Irreversible cell injury IRREVERSIBLE CELL INJURY Persistent ischemia or hypoxia results in irreversible cell injury which leads to cell death. Irreversible cell injury has two phenomenon consistently- Inability to reverse mitochondria dysfunction. Development of disturbances in membrane function. Features of irreversible cell injury- Calcium influx → Mitochondrial damage Due to hypoxia, cytosolic influx of calcium
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