Hemochromatosis HEMOCHROMATOSIS Hemochromatosis is a common inherited disorder of iron metabolism leading to deposition of excessive amount of iron in parenchymal cells leading to fibrosis and organ failure. The iron storage pigment in tissues is called as hemosiderin (least in skin). Hemosiderosis is an acquired condition. Liver is the first organ to be affected & […]
Iron Deficiency Q. 1 Best test to detect iron deficiency in community is – A Transferrin B Serum ferritin C Serum iron D Hemoglobin Q. 1 Best test to detect iron deficiency in community is – A Transferrin B Serum ferritin C Serum iron D Hemoglobin Ans. B Explanation: Ans. is ‘b’ i.e., Serum ferritin
Iron Deficiency IRON DEFICIENCY ANEMIA Iron deficiency can be divided into 3 stages- Negative iron balance Iron deficient erythropoiesis Iron deficiency anemia- microcytic hypochromic anemia Causes of Iron Deficiency Anemia- Increased demand for iron- pregnancy, erythropoietin therapy, growth period. Increased Iron loss- acute & chronic blood loss, phlebotomy Decreased iron absorption- diet, malabsorption of iron,
STRUCTURE OF RNA Q. 1 All of the following statements about Ribozymes are false, EXCEPT: A They are DNA molecules B They are not present in ribosomes C They plays a key role in RNA synthesis D They play a key role in post-transcriptional conversion of pre-mRNA to mature mRNA Q. 1 All of the
STRUCTURE OF RNA STRUCTURE OF RNA RNA is a polymer of ribonucleotides held together by 3’-5’ phosphodiester bridges. Sugar present in RNA is ribose. RNA contains uracil. RNA is a single stranded Mainly seen in cytoplasm. It does not obey Chargaff’s rule. Types of RNA- Messenger RNA (mRNA)- 5-10% Transfer RNA (tRNA)- 10-20% Ribosomal RNA
Regulators & Factors of Heme Synthesis Q. 1 Lead inhibits which enzymes in the heme synthesis pathway: CMC (Vellore) 07 A Aminolevulinate synthase B Ferrochelatase and 6-ALA dehydratase C Porphobilinogen deaminase D Uroporphyrinogen decarboxylase Q. 1 Lead inhibits which enzymes in the heme synthesis pathway: CMC (Vellore) 07 A Aminolevulinate synthase B Ferrochelatase and 6-ALA
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Alkaptonuria Q. 1 Alkaptonuria is caused by defect in which of the following enzymes? A Enolase B Homogentisate oxidase C Pyruvate carboxylase D None of the above Q. 1 Alkaptonuria is caused by defect in which of the following enzymes? A Enolase B Homogentisate oxidase C Pyruvate carboxylase D None of the above Ans. B
ALKAPTONURIA Alkaptonuria (Black Urine Disease) It is due to deficiency of homogentisate oxidase. Inheritance- autosomal recessive disorder. It is a first inborn error detected It belongs to Gerrad’s Tetrad. Homogentisate accumulates in tissues and blood and is excreted into urine. Biochemical Defect- Homogentisic acid is oxidised by polyphenol oxidase to benzoquinone acetate then polymerized to
Regulation & Factors of Heme Synthesis REGULATION & FACTORS OF HEME SYNTHESIS ALA synthase is the key regulatory enzyme in hepatic biosynthesis of Heme. ALA synthase occurs in hepatic and erythrocytes. Factors That Heme Synthesis- Drugs- Barbiturates, Griseofulvin. Lead– inhibits catalyzed by ALA dehydratase and ferrochelatase. INH– decreases PLP. Intracellular buffer due to histidine residue.The
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Metabolism of Aromatic Amino Acids Q. 1 Which of the following is a primary ketone body that is formed from leucine, lysine, phenylalanine and tyrosine? A Acetoacetate B Acetone C Beta hydroxy butyrate D All of the above Q. 1 Which of the following is a primary ketone body that is formed from leucine, lysine,
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